Gene information
Official symbol PRTN3
Official full name proteinase 3
Gene type protein-coding gene
Chromosome19p13.3
Alias symbolPR-3; ACPA; C-ANCA; AGP7; MBT; P29
Gene familyGranule associated serine proteases of immune defence
Resources
Entrez Gene 5657
HGNC HGNC:9495
Ensembl ENSG00000196415
Vega OTTHUMG00000181838
UCSC uc002lqa.2
GO terms: 44 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005766 primary lysosome GO Cellular Components -4.39854337 10 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0006909 phagocytosis GO Biological Processes -7.82039874 17 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0033619 membrane protein proteolysis GO Biological Processes -2.50832748 6 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035578 azurophil granule lumen GO Cellular Components -4.57928114 8 More
GO:0042582 azurophil granule GO Cellular Components -4.39854337 10 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045123 cellular extravasation GO Biological Processes -12.7826256 12 More
GO:0045216 cell-cell junction organization GO Biological Processes -2.57190963 16 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050765 negative regulation of phagocytosis GO Biological Processes -3.64344566 6 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
regramostim NCI 10792393 view
tiprelestat TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
myeloblastin proteomics death;heart failure[prognosis (bad)] acute myocardial infarction Ng LL et al. Clin Sci (Lond). 2011
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